Knowledge Center · Peptides

Ipamorelin

GH secretagogueNot FDA-approvedBanned in sport (WADA)

Ipamorelin is a synthetic, selective growth-hormone secretagogue (a ghrelin-receptor agonist) studied for stimulating GH release with relatively few off-target hormonal effects.

On this pageOverviewWhat is it?MechanismEvidenceApplicationsWhat we knowWhat we don't knowRisksDiscuss with a providerFAQReferences

Overview

Ipamorelin is a selective agonist of the ghrelin/GH-secretagogue receptor that stimulates growth-hormone release. It is valued in research for its selectivity — relatively little effect on cortisol or prolactin compared with older secretagogues — and is often paired with a GHRH analog like CJC-1295.

What is it?

A synthetic research peptide, not an approved medication.

Mechanism of Action

Mechanism:

  • Ghrelin / GH-secretagogue receptor agonism — stimulates pituitary GH release.
  • Selectivity — limited effect on cortisol and prolactin relative to some older agents.
  • Synergy — combined with GHRH analogs to amplify GH pulses in research settings.

Biologically plausible; long-term human outcome data is limited.

Current Scientific Evidence

Early pharmacology supports GH release; long-term human outcome and safety data are limited.

Evidence typeStatus
Human pharmacologySupports GH release with relative selectivity.
Long-term outcomes/safetyLimited.

Potential Clinical Applications (under investigation)

Studied around GH-axis modulation. Not an approved treatment.

What We Know

  • It stimulates GH release relatively selectively.
  • It is not FDA-approved and is prohibited in sport.

What We Don't Know

  • Long-term safety of sustained GH elevation.
  • Optimal protocols.

Potential Risks & Considerations

  • GH-elevation risks over time.
  • Research-grade product quality.
  • Prohibited in sport.
  • Legal status varies.

Who May Wish to Discuss It With Their Provider

Consider only with a licensed provider who can monitor labs and risk. Not a recommendation.

Frequently Asked Questions

Why is Ipamorelin often combined with CJC-1295?

They act on complementary pathways (ghrelin receptor + GHRH receptor), which can amplify GH release in research settings.

Is Ipamorelin FDA approved?

No.

Is it banned in sport?

Yes — GH secretagogues are prohibited under WADA.

Have questions about your own situation?

If you'd like help applying this information to your own health, schedule a consultation with the Bearing team.

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Scientific References

  • Pharmacology literature on Ipamorelin / GH secretagogues — search PubMed.
  • WADA Prohibited List.

References are provided for further reading. Bearing summarizes the literature conservatively and updates pages as evidence evolves.

Related

Peptides: CJC-1295 · Sermorelin · Tools: Peptide Reconstitution Calculator

Educational disclaimer. This page is for general education and is not medical advice. It does not diagnose, treat, or recommend any substance. Many peptides are not FDA-approved; legal status varies and some are prohibited in sport. Discuss any decision with a licensed provider.